DegronMD

Uniprot ID: Q96JN8

Source protein: Neuralized-like protein 4

Source gene: NEURL4

Class: DEG_COP1_1

Location: 685:695

E3 ligase: COP1

DEGRON score: 0.9989

ASA_SCORE: 63.0818

COIL: 0.8183

CONS_SCORE: 0.4053

DSS_SCORE: 0.5544

HELIX: 0.038

FCONS_SCORE: 0.7187

RIG_SCORE: 0.7899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G699W	TCGA-D3-A2JK	SKCM	TCGA	DDVEVAPVPEP	DEG_COP1_1	0.2222
p.G699W	DO37619	SKCM	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.2222
p.E698K	TCGA-EK-A2R8	CESC	TCGA	DDVEVAPVPEP	DEG_COP1_1	0.25
p.E698K	DO51599	CESC	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.25
p.S704F	TCGA-FD-A6TB	BLCA	TCGA	DDVEVAPVPEP	DEG_COP1_1	0.0833
p.S704F	DO51879	BLCA	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.0833
p.V703M	DO233166	GACA	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.1111
p.A681D	DO228974	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.2222
p.N701K	DO229029	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.1667
p.A678E	DO229031	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	0.1389
p.Q680H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DDVEVAPVPEP	DEG_COP1_1	0.1944
p.Q680H	ACH-000953	Leukemia	CCLE	DDVEVAPVPEP	DEG_COP1_1	0.1944
p.Q680H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DDVEVAPVPEP	DEG_COP1_1	0.1944
p.S704Y	SIDM00217	Colorectal Carcinoma	GDSC	DDVEVAPVPEP	DEG_COP1_1	0.0833
p.S704Y	ACH-000999	Colon/Colorectal Cancer	CCLE	DDVEVAPVPEP	DEG_COP1_1	0.0833
p.S704Y	SNU-1040	large_intestine	COSMIC	DDVEVAPVPEP	DEG_COP1_1	0.0833
p.Q677H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	DDVEVAPVPEP	DEG_COP1_1	0.1111
p.Q677H	ACH-000942	Leukemia	CCLE	DDVEVAPVPEP	DEG_COP1_1	0.1111
p.S682Y	SNU-1040	large_intestine	COSMIC	DDVEVAPVPEP	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JN8	Neuralized-like protein 4	DEG_COP1_1	685:695	DDVEVAPVPEP	COP1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons