DegronMD - Q96JN8(NEURL4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G699W	TCGA-D3-A2JK	SKCM	TCGA	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.2222
p.G699W	DO37619	SKCM	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.2222
p.T215A	TCGA-E6-A1M0	UCEC	TCGA	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7139
p.T215A	DO43682	UCEC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7139
p.P221S	TCGA-EE-A2MS	SKCM	TCGA	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.5641
p.P221S	TCGA-W3-AA1Q	SKCM	TCGA	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.5641
p.P221S	DO37567	SKCM	ICGC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.5641
p.P221S	DO219487	SKCM	ICGC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.5641
p.E698K	TCGA-EK-A2R8	CESC	TCGA	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.25
p.E698K	DO51599	CESC	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.25
p.S704F	TCGA-FD-A6TB	BLCA	TCGA	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.0833
p.S704F	DO51879	BLCA	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.0833
p.V703M	DO233166	GACA	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1111
p.A681D	DO228974	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.2222
p.N701K	DO229029	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1667
p.A678E	DO229031	LICA	ICGC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1389
p.P214H	DO230535	LUSC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6583
p.P214H	DO231070	LUSC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6583
p.S212I	SIDM01954	Colorectal Carcinoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.3056
p.S212I	SIDM01954	Colorectal Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.2222
p.P224A	SIDM00607	Glioblastoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1944
p.P224A	SIDM00607	Glioblastoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.3056
p.P224A	SIDM00083	Glioblastoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1944
p.P224A	SIDM00083	Glioblastoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.3056
p.P224A	ACH-000622	Brain Cancer	CCLE	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1944
p.P224A	ACH-000622	Brain Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.3056
p.P224A	KNS-42	central nervous system	COSMIC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1944
p.P224A	KNS-42	central nervous system	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.3056
p.Q680H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1944
p.Q680H	ACH-000953	Leukemia	CCLE	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1944
p.Q680H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1944
p.P216S	SIDM00527	Colorectal Carcinoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6752
p.P216S	SIDM00527	Colorectal Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.6752
p.P216S	ACH-000935	Colon/Colorectal Cancer	CCLE	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6752
p.P216S	ACH-000935	Colon/Colorectal Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.6752
p.P216S	MDST8	large intestine	COSMIC	PPTPIPT	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6752
p.P216S	MDST8	large intestine	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation altering degron motif	0.6752
p.S231F	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.1111
p.S231F	ACH-000873	Esophageal Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.1111
p.S231F	KYSE-270	oesophagus	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	216:223	Mutation rewiring degron network	0.1111
p.S704Y	SIDM00217	Colorectal Carcinoma	GDSC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.0833
p.S704Y	ACH-000999	Colon/Colorectal Cancer	CCLE	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.0833
p.S704Y	SNU-1040	large intestine	COSMIC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.0833
p.Q677H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1111
p.Q677H	ACH-000942	Leukemia	CCLE	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.1111
p.S682Y	SNU-1040	large intestine	COSMIC	DDVEVAPVPEP	DEG_COP1_1	685:695	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEURL4

UniProt ID: Q96JN8

Entrez ID: 84461

Protein name: Neuralized-like protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEURL4 in