DegronMD

Uniprot ID: Q96JN8

Source protein: Neuralized-like protein 4

Source gene: NEURL4

Class: DEG_SCF_FBW7_1

Location: 213:219

E3 ligase: FBXW7

DEGRON score: 0.7632

ASA_SCORE: 88.3286

COIL: 0.9653

CONS_SCORE: 0.2611

DSS_SCORE: 0.7143

HELIX: 0.0077

FCONS_SCORE: 0.8881

RIG_SCORE: 0.6197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T215A	TCGA-E6-A1M0	UCEC	TCGA	PPTPIPT	DEG_SCF_FBW7_1	0.7139
p.T215A	DO43682	UCEC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	0.7139
p.P214H	DO230535	LUSC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	0.6583
p.P214H	DO231070	LUSC	ICGC	PPTPIPT	DEG_SCF_FBW7_1	0.6583
p.S212I	SIDM01954	Colorectal Carcinoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	0.3056
p.P224A	SIDM00607	Glioblastoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	0.1944
p.P224A	SIDM00083	Glioblastoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	0.1944
p.P224A	ACH-000622	Brain Cancer	CCLE	PPTPIPT	DEG_SCF_FBW7_1	0.1944
p.P224A	KNS-42	central_nervous_system	COSMIC	PPTPIPT	DEG_SCF_FBW7_1	0.1944
p.P216S	SIDM00527	Colorectal Carcinoma	GDSC	PPTPIPT	DEG_SCF_FBW7_1	0.6752
p.P216S	ACH-000935	Colon/Colorectal Cancer	CCLE	PPTPIPT	DEG_SCF_FBW7_1	0.6752
p.P216S	MDST8	large_intestine	COSMIC	PPTPIPT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JN8	Neuralized-like protein 4	DEG_SCF_FBW7_1	213:219	PPTPIPT	FBXW7	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons