DegronMD

Uniprot ID: Q96JN8

Source protein: Neuralized-like protein 4

Source gene: NEURL4

Class: DEG_SCF_FBW7_2

Location: 216:223

E3 ligase: FBXW7

DEGRON score: 0.7737

ASA_SCORE: 94.725

COIL: 0.9669

CONS_SCORE: 0.2407

DSS_SCORE: 0.7504

HELIX: 0.0118

FCONS_SCORE: 0.9603

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P221S	TCGA-EE-A2MS	SKCM	TCGA	PIPTPPLE	DEG_SCF_FBW7_2	0.5641
p.P221S	TCGA-W3-AA1Q	SKCM	TCGA	PIPTPPLE	DEG_SCF_FBW7_2	0.5641
p.P221S	DO37567	SKCM	ICGC	PIPTPPLE	DEG_SCF_FBW7_2	0.5641
p.P221S	DO219487	SKCM	ICGC	PIPTPPLE	DEG_SCF_FBW7_2	0.5641
p.S212I	SIDM01954	Colorectal Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	0.2222
p.P224A	SIDM00607	Glioblastoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	0.3056
p.P224A	SIDM00083	Glioblastoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	0.3056
p.P224A	ACH-000622	Brain Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	0.3056
p.P224A	KNS-42	central_nervous_system	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	0.3056
p.P216S	SIDM00527	Colorectal Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	0.6752
p.P216S	ACH-000935	Colon/Colorectal Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	0.6752
p.P216S	MDST8	large_intestine	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	0.6752
p.S231F	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PIPTPPLE	DEG_SCF_FBW7_2	0.1111
p.S231F	ACH-000873	Esophageal Cancer	CCLE	PIPTPPLE	DEG_SCF_FBW7_2	0.1111
p.S231F	KYSE-270	oesophagus	COSMIC	PIPTPPLE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JN8	Neuralized-like protein 4	DEG_SCF_FBW7_2	216:223	PIPTPPLE	FBXW7	0.7737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons