DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: CBL_PTK

Location: 1880:1886

E3 ligase: CBL

DEGRON score: 0.6273

ASA_SCORE: 68.9

COIL: 0.6944

CONS_SCORE: 0.3137

DSS_SCORE: 0.0814

HELIX: 0.1084

FCONS_SCORE: -0.0008

RIG_SCORE: 0.7887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1896M	TCGA-12-3651	GBM	TCGA	DDYSHCP	CBL_PTK	0.0556
p.T1896M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DDYSHCP	CBL_PTK	0.0556
p.T1896M	ACH-000717	Esophageal Cancer	CCLE	DDYSHCP	CBL_PTK	0.0556
p.T1896M	COLO-680N	oesophagus	COSMIC	DDYSHCP	CBL_PTK	0.0556
p.R1875C	TCGA-AP-A1DV	UCEC	TCGA	DDYSHCP	CBL_PTK	0.1944
p.T1894M	TCGA-B5-A11H	UCEC	TCGA	DDYSHCP	CBL_PTK	0.1111
p.A1895T	TCGA-CV-7568	HNSC	TCGA	DDYSHCP	CBL_PTK	0.0833
p.D1881N	TCGA-EO-A22U	UCEC	TCGA	DDYSHCP	CBL_PTK	0.5821
p.S1896Y	DO15238	HNSC	ICGC	DDYSHCP	CBL_PTK	0.0556
p.R1878L	DO228952	LICA	ICGC	DDYSHCP	CBL_PTK	0.2778
p.R1878C	DO43186	UCEC	ICGC	DDYSHCP	CBL_PTK	0.2778
p.D1884N	DO43755	UCEC	ICGC	DDYSHCP	CBL_PTK	0.6932
p.N1871S	SIDM00684	Glioblastoma	GDSC	DDYSHCP	CBL_PTK	0.0833
p.N1871S	ACH-000595	Brain Cancer	CCLE	DDYSHCP	CBL_PTK	0.0833
p.N1871S	LN-229	central_nervous_system	COSMIC	DDYSHCP	CBL_PTK	0.0833
p.Y1882C	SIDM00683	Prostate Carcinoma	GDSC	DDYSHCP	CBL_PTK	0.7087
p.Y1882C	LNCaP-Clone-FGC	prostate	COSMIC	DDYSHCP	CBL_PTK	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	CBL_PTK	1880:1886	DDYSHCP	CBL	0.6273	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons