DegronMD

Uniprot ID: Q6NSI3

Source protein: Protein FAM53A

Source gene: FAM53A

Class: DEG_SCF_SKP2-CKS1_1

Location: 311:318

E3 ligase: SKP2,CSK1

DEGRON score: 0.9792

ASA_SCORE: 103.725

COIL: 0.9219

CONS_SCORE: 0.5215

DSS_SCORE: 0.4949

HELIX: 0.0381

FCONS_SCORE: 0.8739

RIG_SCORE: 0.7442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D311N	TCGA-06-5416	GBM	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.5821
p.D311N	DO10880	GBM	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.5821
p.P324S	TCGA-77-A5GH	LUSC	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P324S	DO45452	LUSC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.C325Y	TCGA-CG-4460	STAD	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1389
p.C325Y	DO38427	STAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1389
p.V311M	DO8447	COAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.7208
p.V311M	DO34120	PACA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.7208
p.S323Y	DO234274	ESAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1944
p.T319M	DO233188	GACA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E308K	DO45083	LINC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.S312T	DO230525	LUSC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.7116
p.S326L	DO222908	MELA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1111
p.L302F	DO232761	PBCA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S317L	DO42023	UCEC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.7667
p.L328P	SIDM01278	Colorectal Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.0556
p.L305F	SIDM00473	Oral Cavity Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.L305F	SIDM00640	Mesothelioma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E308D	SIDM01622	Breast Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.E301K	ACH-001669	Leukemia	CCLE	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSI3	Protein FAM53A	DEG_SCF_SKP2-CKS1_1	311:318	DEDDTPVK	SKP2,CSK1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons