DegronMD - Q6NSI3(FAM53A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D311N	TCGA-06-5416	GBM	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.5821
p.D311N	DO10880	GBM	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.5821
p.P324S	TCGA-77-A5GH	LUSC	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1667
p.P324S	DO45452	LUSC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1667
p.S286F	TCGA-CD-5800	STAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.6871
p.S286F	DO38431	STAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.6871
p.C325Y	TCGA-CG-4460	STAD	TCGA	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1389
p.C325Y	DO38427	STAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1389
p.G193C	TCGA-DD-AACE	LIHC	TCGA	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.1944
p.G193C	DO52200	LIHC	ICGC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.1944
p.P285S	TCGA-FJ-A3ZE	BLCA	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.5641
p.P285S	DO484	BLCA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.5641
p.M292I	TCGA-J9-A52C	PRAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.3056
p.M292I	DO51343	PRAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.3056
p.R284H	TCGA-VQ-A91D	STAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.8244
p.R284H	DO51783	STAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation altering degron motif	0.8244
p.R152W	DO9074	COAD	ICGC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.2778
p.V311M	DO8447	COAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.7208
p.V311M	DO34120	PACA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.7208
p.S181L	DO229010	COCA	ICGC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.3056
p.S323Y	DO234274	ESAD	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1944
p.A280T	DO233146	GACA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.25
p.T319M	DO233188	GACA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.3056
p.E277Q	DO233838	GACA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1667
p.A299S	DO228390	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1111
p.R276S	DO228976	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1389
p.R276S	DO229029	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1389
p.Q294K	DO228985	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.25
p.T295N	DO229035	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.2222
p.R276H	DO229052	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1389
p.E308K	DO45083	LINC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.25
p.S312T	DO230525	LUSC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.7116
p.S189F	DO220885	MELA	ICGC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.3056
p.S326L	DO222908	MELA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1111
p.T180P	DO35672	PBCA	ICGC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.2778
p.L302F	DO232761	PBCA	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.0833
p.R281M	DO232224	PBCA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.2778
p.V195M	DO38376	STAD	ICGC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.1389
p.S317L	DO42023	UCEC	ICGC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation altering degron motif	0.7667
p.T184M	SIDM02026	Colorectal Carcinoma	GDSC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation altering degron motif	0.7423
p.L328P	SIDM01278	Colorectal Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.0556
p.T146S	SIDM01020	Plasma Cell Myeloma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00553	Acute Myeloid Leukemia	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00555	Glioblastoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00394	Cervical Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00997	Thyroid Gland Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM01735	Biliary Tract Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM01347	Ovarian Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM01469	Pancreatic Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.T146S	SIDM00159	Biliary Tract Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1111
p.L305F	SIDM00473	Oral Cavity Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1667
p.L305F	SIDM00640	Mesothelioma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.1667
p.S197I	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.0833
p.E308D	SIDM01622	Breast Carcinoma	GDSC	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.25
p.R161Q	SIDM00780	Colorectal Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.3056
p.R161Q	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.3056
p.R276C	SIDM00011	Melanoma	GDSC	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.1389
p.G166S	SIDM01777	Pancreatic Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1667
p.T177A	ACH-000982	Colon/Colorectal Cancer	CCLE	PATPRPS	DEG_SCF_FBW7_1	182:188	Mutation rewiring degron network	0.1944
p.P165H	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGGSAT	DEG_SCF_TRCP1_1	154:160	Mutation rewiring degron network	0.1944
p.E301K	ACH-001669	Leukemia	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.0556
p.E301K	ACH-001669	Leukemia	CCLE	DEDDTPVK	DEG_SCF_SKP2-CKS1_1	311:318	Mutation rewiring degron network	0.0556
p.W282C	ACH-002509	Skin Cancer	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.3056
p.W282L	ACH-002509	Skin Cancer	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	283:291	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM53A

UniProt ID: Q6NSI3

Entrez ID: 152877

Protein name: Protein FAM53A (Dorsal neural-tube nuclear protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM53A in