DegronMD

Uniprot ID: Q6NSI3

Source protein: Protein FAM53A

Source gene: FAM53A

Class: DEG_SCF_TRCP1_1

Location: 154:160

E3 ligase: BTRC

DEGRON score: 0.9818

ASA_SCORE: 63.4

COIL: 0.7889

CONS_SCORE: 0.8872

DSS_SCORE: 0.6042

HELIX: 0.0674

FCONS_SCORE: 1.1143

RIG_SCORE: 0.6132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R152W	DO9074	COAD	ICGC	DSGGSAT	DEG_SCF_TRCP1_1	0.2778
p.T146S	SIDM01020	Plasma Cell Myeloma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00553	Acute Myeloid Leukemia	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00555	Glioblastoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00394	Cervical Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00997	Thyroid Gland Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM01735	Biliary Tract Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM01347	Ovarian Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM01469	Pancreatic Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.T146S	SIDM00159	Biliary Tract Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1111
p.R161Q	SIDM00780	Colorectal Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.3056
p.R161Q	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGGSAT	DEG_SCF_TRCP1_1	0.3056
p.G166S	SIDM01777	Pancreatic Carcinoma	GDSC	DSGGSAT	DEG_SCF_TRCP1_1	0.1667
p.P165H	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGGSAT	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSI3	Protein FAM53A	DEG_SCF_TRCP1_1	154:160	DSGGSAT	BTRC	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons