DegronMD

Uniprot ID: Q6NSI3

Source protein: Protein FAM53A

Source gene: FAM53A

Class: DEG_SCF_FBW7_1

Location: 182:188

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 71.9143

COIL: 0.9183

CONS_SCORE: 0.7484

DSS_SCORE: 0.6257

HELIX: 0.0311

FCONS_SCORE: 1.0569

RIG_SCORE: 0.5988

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G193C	TCGA-DD-AACE	LIHC	TCGA	PATPRPS	DEG_SCF_FBW7_1	0.1944
p.G193C	DO52200	LIHC	ICGC	PATPRPS	DEG_SCF_FBW7_1	0.1944
p.S181L	DO229010	COCA	ICGC	PATPRPS	DEG_SCF_FBW7_1	0.3056
p.S189F	DO220885	MELA	ICGC	PATPRPS	DEG_SCF_FBW7_1	0.3056
p.T180P	DO35672	PBCA	ICGC	PATPRPS	DEG_SCF_FBW7_1	0.2778
p.V195M	DO38376	STAD	ICGC	PATPRPS	DEG_SCF_FBW7_1	0.1389
p.T184M	SIDM02026	Colorectal Carcinoma	GDSC	PATPRPS	DEG_SCF_FBW7_1	0.7423
p.S197I	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PATPRPS	DEG_SCF_FBW7_1	0.0833
p.T177A	ACH-000982	Colon/Colorectal Cancer	CCLE	PATPRPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSI3	Protein FAM53A	DEG_SCF_FBW7_1	182:188	PATPRPS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons