DegronMD

Uniprot ID: Q6NSI3

Source protein: Protein FAM53A

Source gene: FAM53A

Class: DEG_APCC_DBOX_1

Location: 283:291

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7132

ASA_SCORE: 74.7667

COIL: 0.5526

CONS_SCORE: 0.9209

DSS_SCORE: 0.4021

HELIX: 0.4061

FCONS_SCORE: 1.111

RIG_SCORE: 0.7953

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R284H	TCGA-VQ-A91D	STAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	0.8244
p.R284H	DO51783	STAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.8244
p.S286F	TCGA-CD-5800	STAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	0.6871
p.S286F	DO38431	STAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.6871
p.P285S	TCGA-FJ-A3ZE	BLCA	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	0.5641
p.P285S	DO484	BLCA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.5641
p.M292I	TCGA-J9-A52C	PRAD	TCGA	TRPSLDFLK	DEG_APCC_DBOX_1	0.3056
p.M292I	DO51343	PRAD	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.3056
p.W282C	ACH-002509	Skin Cancer	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	0.3056
p.W282L	ACH-002509	Skin Cancer	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	0.3056
p.R281M	DO232224	PBCA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.2778
p.A280T	DO233146	GACA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.25
p.Q294K	DO228985	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.25
p.T295N	DO229035	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.2222
p.E277Q	DO233838	GACA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1667
p.R276S	DO228976	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1389
p.R276S	DO229029	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1389
p.R276H	DO229052	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1389
p.R276C	SIDM00011	Melanoma	GDSC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1389
p.A299S	DO228390	LICA	ICGC	TRPSLDFLK	DEG_APCC_DBOX_1	0.1111
p.E301K	ACH-001669	Leukemia	CCLE	TRPSLDFLK	DEG_APCC_DBOX_1	0.0556

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSI3	Protein FAM53A	DEG_APCC_DBOX_1	283:291	TRPSLDFLK	APC,CDC20,FZR1	0.7132	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons