DegronMD

Uniprot ID: Q96K17

Source protein: Transcription factor BTF3 homolog 4

Source gene: BTF3L4

Class: DEG_COP1_1

Location: 136:145

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 79.69

COIL: 0.7803

CONS_SCORE: 0.8044

DSS_SCORE: 0.7434

HELIX: 0.1878

FCONS_SCORE: 1.2172

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L145I	TCGA-24-1846	OV	TCGA	DEEDDDVPDL	DEG_COP1_1	0.6063
p.N148K	TCGA-EO-A22U	UCEC	TCGA	DEEDDDVPDL	DEG_COP1_1	0.25
p.N148K	DO43755	UCEC	ICGC	DEEDDDVPDL	DEG_COP1_1	0.25
p.V146G	TCGA-PK-A5HB	ACC	TCGA	DEEDDDVPDL	DEG_COP1_1	0.3056
p.D141G	TCGA-XF-AAMJ	BLCA	TCGA	DEEDDDVPDL	DEG_COP1_1	0.6087
p.D141G	DO51932	BLCA	ICGC	DEEDDDVPDL	DEG_COP1_1	0.6087
p.A152V	DO222427	BTCA	ICGC	DEEDDDVPDL	DEG_COP1_1	0.1389
p.D150Y	DO228952	LICA	ICGC	DEEDDDVPDL	DEG_COP1_1	0.1944
p.D139Y	SIDM00789	Colorectal Carcinoma	GDSC	DEEDDDVPDL	DEG_COP1_1	0.6214
p.D139Y	ACH-000997	Colon/Colorectal Cancer	CCLE	DEEDDDVPDL	DEG_COP1_1	0.6214
p.D139Y	ACH-001061	Colon/Colorectal Cancer	CCLE	DEEDDDVPDL	DEG_COP1_1	0.6214
p.D139Y	HCT-15	large_intestine	COSMIC	DEEDDDVPDL	DEG_COP1_1	0.6214
p.D134Y	SIDM00534	Colorectal Carcinoma	GDSC	DEEDDDVPDL	DEG_COP1_1	0.2778
p.D134Y	ACH-000986	Colon/Colorectal Cancer	CCLE	DEEDDDVPDL	DEG_COP1_1	0.2778
p.D134Y	HT-115	large_intestine	COSMIC	DEEDDDVPDL	DEG_COP1_1	0.2778
p.D134H	ACH-000029	Lung Cancer	CCLE	DEEDDDVPDL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K17	Transcription factor BTF3 homolog 4	DEG_COP1_1	136:145	DEEDDDVPDL	COP1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons