DegronMD

Uniprot ID: Q9NQS7

Source protein: Inner centromere protein

Source gene: INCENP

Class: DEG_SCF_SKP2-CKS1_1

Location: 215:222

E3 ligase: SKP2,CSK1

DEGRON score: 0.9981

ASA_SCORE: 95.8625

COIL: 0.7541

CONS_SCORE: 0.4281

DSS_SCORE: 0.6955

HELIX: 0.1994

FCONS_SCORE: 1.2908

RIG_SCORE: 0.6464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P212L	TCGA-EO-A22U	UCEC	TCGA	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.P212L	DO43755	UCEC	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.S208Y	DO225325	BRCA	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.L228M	DO228464	LICA	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P206A	SIDM00252	Biliary Tract Carcinoma	GDSC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P206A	ACH-001861	Gallbladder Cancer	CCLE	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P206A	TGBC1TKB	biliary_tract	COSMIC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQS7	Inner centromere protein	DEG_SCF_SKP2-CKS1_1	215:222	DEESTPKK	SKP2,CSK1	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons