DegronMD - Q9NQS7(INCENP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T494S	TCGA-86-8054	LUAD	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation altering degron motif	0.7116
p.T494S	DO23923	LUAD	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation altering degron motif	0.7116
p.P491A	TCGA-90-A4EE	LUSC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.3056
p.P491A	DO45513	LUSC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.3056
p.L492P	TCGA-AK-3444	KIRC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation altering degron motif	0.6471
p.R490W	TCGA-DX-AB2W	SARC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.2778
p.R490W	DO220095	SARC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.2778
p.P212L	TCGA-EO-A22U	UCEC	TCGA	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.25
p.P212L	DO43755	UCEC	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.25
p.R490Q	TCGA-EO-A3AU	UCEC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.2778
p.R490Q	DO43827	UCEC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.2778
p.S208Y	DO225325	BRCA	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation blocking phosphorylation signal	0.5833
p.L228M	DO228464	LICA	ICGC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.1667
p.M506T	DO228941	LICA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.1667
p.H497L	DO232855	NACA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation altering degron motif	0.6202
p.P484T	DO229208	THCA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.1111
p.V488M	SIDM01307	Colorectal Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.2222
p.R501K	SIDM00845	Burkitt's Lymphoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.3056
p.M506I	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.1667
p.M506I	SIDM01000	Melanoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.1667
p.M506I	SIDM00528	Breast Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation rewiring degron network	0.1667
p.P206A	SIDM00252	Biliary Tract Carcinoma	GDSC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.0833
p.P206A	ACH-001861	Gallbladder Cancer	CCLE	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.0833
p.P206A	TGBC1TKB	biliary tract	COSMIC	DEESTPKK	DEG_SCF_SKP2-CKS1_1	215:222	Mutation rewiring degron network	0.0833
p.S486R	ACH-000836	Head and Neck Cancer	CCLE	LRTFLHTVQ	DEG_APCC_DBOX_1	492:500	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for INCENP in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INCENP

UniProt ID: Q9NQS7

Entrez ID: 3619

Protein name: Inner centromere protein

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for INCENP in