DegronMD

Uniprot ID: Q9NQS7

Source protein: Inner centromere protein

Source gene: INCENP

Class: DEG_APCC_DBOX_1

Location: 492:500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6661

ASA_SCORE: 87.7111

COIL: 0.4179

CONS_SCORE: 0.4022

DSS_SCORE: 0.4843

HELIX: 0.5341

FCONS_SCORE: 0.8559

RIG_SCORE: 0.8063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T494S	TCGA-86-8054	LUAD	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	0.7116
p.T494S	DO23923	LUAD	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.7116
p.P491A	TCGA-90-A4EE	LUSC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	0.3056
p.P491A	DO45513	LUSC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.3056
p.L492P	TCGA-AK-3444	KIRC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	0.6471
p.R490W	TCGA-DX-AB2W	SARC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	0.2778
p.R490W	DO220095	SARC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.2778
p.R490Q	TCGA-EO-A3AU	UCEC	TCGA	LRTFLHTVQ	DEG_APCC_DBOX_1	0.2778
p.R490Q	DO43827	UCEC	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.2778
p.M506T	DO228941	LICA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.1667
p.H497L	DO232855	NACA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.6202
p.P484T	DO229208	THCA	ICGC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.1111
p.V488M	SIDM01307	Colorectal Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.2222
p.R501K	SIDM00845	Burkitt's Lymphoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.3056
p.M506I	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.1667
p.M506I	SIDM01000	Melanoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.1667
p.M506I	SIDM00528	Breast Carcinoma	GDSC	LRTFLHTVQ	DEG_APCC_DBOX_1	0.1667
p.S486R	ACH-000836	Head and Neck Cancer	CCLE	LRTFLHTVQ	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQS7	Inner centromere protein	DEG_APCC_DBOX_1	492:500	LRTFLHTVQ	APC,CDC20,FZR1	0.6661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons