DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DEMKEYYSKNP
Uniprot ID:
Q8NHU6
Source protein:
Tudor domain-containing protein 7
Source gene:
TDRD7
Class:
CBL_PTK
Location:
496:506
E3 ligase:
CBL
DEGRON score:
0.6869
ASA_SCORE:
85.4545
COIL:
0.3113
CONS_SCORE:
0.5215
DSS_SCORE:
0.3458
HELIX:
0.6829
FCONS_SCORE:
1.149
RIG_SCORE:
0.7961
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D496H
TCGA-AP-A0LM
UCEC
TCGA
DEMKEYYSKNP
CBL_PTK
0.7688
p.D496H
DO43306
UCEC
ICGC
DEMKEYYSKNP
CBL_PTK
0.7688
p.S503G
TCGA-BG-A0VZ
UCEC
TCGA
DEMKEYYSKNP
CBL_PTK
0.6993
p.S503G
DO42368
UCEC
ICGC
DEMKEYYSKNP
CBL_PTK
0.6993
p.Y502H
DO222798
COCA
ICGC
DEMKEYYSKNP
CBL_PTK
0.834
p.Y502C
DO222877
COCA
ICGC
DEMKEYYSKNP
CBL_PTK
0.8198
Drug responses associated with TDRD7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DEMKEYYSKNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NHU6
Tudor domain-containing protein 7
CBL_PTK
496:506
DEMKEYYSKNP
CBL
0.6869
More...
