DegronMD - Q8NHU6(TDRD7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D496H	TCGA-AP-A0LM	UCEC	TCGA	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.7688
p.D496H	DO43306	UCEC	ICGC	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.7688
p.S870L	TCGA-AX-A2HC	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1389
p.S870L	DO41572	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1389
p.S503G	TCGA-BG-A0VZ	UCEC	TCGA	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.6993
p.S503G	DO42368	UCEC	ICGC	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.6993
p.A895T	TCGA-BR-4184	STAD	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.0556
p.A895T	DO38328	STAD	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.0556
p.A895T	SIDM00674	Non-Cancerous	GDSC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.0556
p.T893A	TCGA-DI-A1BU	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1111
p.T893A	DO42023	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1111
p.T893M	TCGA-EY-A1GO	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1111
p.T893M	DO41392	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1111
p.E875D	TCGA-F5-6814	READ	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.2778
p.E875D	DO36556	READ	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.2778
p.G871C	TCGA-FD-A6TE	BLCA	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1667
p.G871C	DO49759	BLCA	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1667
p.Y502H	DO222798	COCA	ICGC	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.834
p.Y502C	DO222877	COCA	ICGC	DEMKEYYSKNP	CBL_PTK	496:506	Mutation altering degron motif	0.8198
p.H892R	DO228828	LICA	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	877:885	Mutation rewiring degron network	0.1389

Kaplan plot for TDRD7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDRD7

UniProt ID: Q8NHU6

Entrez ID: 23424

Protein name: Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TDRD7 in