DegronMD

Uniprot ID: Q8NHU6

Source protein: Tudor domain-containing protein 7

Source gene: TDRD7

Class: DEG_APCC_DBOX_1

Location: 877:885

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8014

ASA_SCORE: 82.6667

COIL: 0.5293

CONS_SCORE: 0.3439

DSS_SCORE: 0.5252

HELIX: 0.2921

FCONS_SCORE: 1.0699

RIG_SCORE: 0.768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S870L	TCGA-AX-A2HC	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.1389
p.S870L	DO41572	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.1389
p.A895T	TCGA-BR-4184	STAD	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.0556
p.A895T	DO38328	STAD	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.0556
p.A895T	SIDM00674	Non-Cancerous	GDSC	FRKNLTDVI	DEG_APCC_DBOX_1	0.0556
p.T893A	TCGA-DI-A1BU	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.1111
p.T893A	DO42023	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.1111
p.T893M	TCGA-EY-A1GO	UCEC	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.1111
p.T893M	DO41392	UCEC	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.1111
p.E875D	TCGA-F5-6814	READ	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.2778
p.E875D	DO36556	READ	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.2778
p.G871C	TCGA-FD-A6TE	BLCA	TCGA	FRKNLTDVI	DEG_APCC_DBOX_1	0.1667
p.G871C	DO49759	BLCA	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.1667
p.H892R	DO228828	LICA	ICGC	FRKNLTDVI	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHU6	Tudor domain-containing protein 7	DEG_APCC_DBOX_1	877:885	FRKNLTDVI	APC,CDC20,FZR1	0.8014	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons