DegronMD

Uniprot ID: P17535

Source protein: Transcription factor JunD

Source gene: JUND

Class: DEG_COP1_1

Location: 241:252

E3 ligase: COP1

DEGRON score: 0.9936

ASA_SCORE: 101.6583

COIL: 0.9546

CONS_SCORE: 0.4822

DSS_SCORE: 0.7163

HELIX: 0.026

FCONS_SCORE: 1.0176

RIG_SCORE: 0.6354

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S251N	TCGA-39-5021	LUSC	TCGA	DEPQTVPDVPSF	DEG_COP1_1	0.7069
p.S251N	DO27397	LUSC	ICGC	DEPQTVPDVPSF	DEG_COP1_1	0.7069
p.E242K	TCGA-4Z-AA7R	BLCA	TCGA	DEPQTVPDVPSF	DEG_COP1_1	0.7022
p.E242K	DO51866	BLCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	0.7022
p.S259W	TCGA-DK-A2I4	BLCA	TCGA	DEPQTVPDVPSF	DEG_COP1_1	0.5833
p.S259W	DO465	BLCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	0.5833
p.K240N	DO234209	ESAD	ICGC	DEPQTVPDVPSF	DEG_COP1_1	0.3056
p.P250S	DO48940	PBCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	0.5641
p.P233L	SIDM00303	Ovarian Carcinoma	GDSC	DEPQTVPDVPSF	DEG_COP1_1	0.1111
p.P233L	ACH-000584	Ovarian Cancer	CCLE	DEPQTVPDVPSF	DEG_COP1_1	0.1111
p.T245A	ACH-000922	Leukemia	CCLE	DEPQTVPDVPSF	DEG_COP1_1	0.6028
p.T245A	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DEPQTVPDVPSF	DEG_COP1_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17535	Transcription factor JunD	DEG_COP1_1	241:252	DEPQTVPDVPSF	COP1	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons