DegronMD - P17535(JUND)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S251N	TCGA-39-5021	LUSC	TCGA	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.7069
p.S251N	DO27397	LUSC	ICGC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.7069
p.S121L	TCGA-39-5031	LUSC	TCGA	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7667
p.S121L	DO26526	LUSC	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7667
p.E242K	TCGA-4Z-AA7R	BLCA	TCGA	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.7022
p.E242K	DO51866	BLCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.7022
p.T115I	TCGA-CK-4951	COAD	TCGA	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.5966
p.T115I	DO10582	COAD	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.5966
p.S259W	TCGA-DK-A2I4	BLCA	TCGA	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation blocking phosphorylation signal	0.5833
p.S259W	DO465	BLCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation blocking phosphorylation signal	0.5833
p.T115S	DO225267	BRCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.6005
p.K240N	DO234209	ESAD	ICGC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation rewiring degron network	0.3056
p.P250S	DO48940	PBCA	ICGC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.5641
p.R105C	DO229224	THCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.0833
p.A130S	DO229092	THCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.0833
p.K127T	SIDM02062	Colorectal Carcinoma	GDSC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation blocking ubiquitination signal	0.6111
p.P233L	SIDM00303	Ovarian Carcinoma	GDSC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation rewiring degron network	0.1111
p.P233L	ACH-000584	Ovarian Cancer	CCLE	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation rewiring degron network	0.1111
p.S120N	SIDM00225	Melanoma	GDSC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.5958
p.S120N	IST-MEL1	skin	COSMIC	VTTTPTSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.5958
p.T245A	ACH-000922	Leukemia	CCLE	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.6028
p.T245A	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DEPQTVPDVPSF	DEG_COP1_1	241:252	Mutation altering degron motif	0.6028

Kaplan plot for JUND in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JUND

UniProt ID: P17535

Entrez ID: 3727

Protein name: Transcription factor JunD (Transcription factor AP-1 subunit JunD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JUND in