DegronMD

Uniprot ID: P17535

Source protein: Transcription factor JunD

Source gene: JUND

Class: DEG_SCF_FBW7_1

Location: 114:121

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 63.625

COIL: 0.8155

CONS_SCORE: 0.5293

DSS_SCORE: 0.274

HELIX: 0.0755

FCONS_SCORE: 1.0616

RIG_SCORE: 0.7545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S121L	TCGA-39-5031	LUSC	TCGA	VTTTPTSS	DEG_SCF_FBW7_1	0.7667
p.S121L	DO26526	LUSC	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	0.7667
p.T115I	TCGA-CK-4951	COAD	TCGA	VTTTPTSS	DEG_SCF_FBW7_1	0.5966
p.T115I	DO10582	COAD	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	0.5966
p.T115S	DO225267	BRCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	0.6005
p.R105C	DO229224	THCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	0.0833
p.A130S	DO229092	THCA	ICGC	VTTTPTSS	DEG_SCF_FBW7_1	0.0833
p.K127T	SIDM02062	Colorectal Carcinoma	GDSC	VTTTPTSS	DEG_SCF_FBW7_1	0.6111
p.S120N	SIDM00225	Melanoma	GDSC	VTTTPTSS	DEG_SCF_FBW7_1	0.5958
p.S120N	IST-MEL1	skin	COSMIC	VTTTPTSS	DEG_SCF_FBW7_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17535	Transcription factor JunD	DEG_SCF_FBW7_1	114:121	VTTTPTSS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons