DegronMD

Uniprot ID: Q6P2D8

Source protein: X-ray radiation resistance-associated protein 1

Source gene: XRRA1

Class: CBL_PTK

Location: 309:318

E3 ligase: CBL

DEGRON score: 0.9704

ASA_SCORE: 71.6

COIL: 0.6806

CONS_SCORE: 0.2744

DSS_SCORE: 0.4728

HELIX: 0.2566

FCONS_SCORE: 1.0227

RIG_SCORE: 0.7987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D322N	TCGA-91-A4BC	LUAD	TCGA	DEQLDYTVLP	CBL_PTK	0.2222
p.D322N	DO45422	LUAD	ICGC	DEQLDYTVLP	CBL_PTK	0.2222
p.D309H	TCGA-AR-A250	BRCA	TCGA	DEQLDYTVLP	CBL_PTK	0.7688
p.M304L	TCGA-HU-A4GU	STAD	TCGA	DEQLDYTVLP	CBL_PTK	0.1944
p.M304L	DO47849	STAD	ICGC	DEQLDYTVLP	CBL_PTK	0.1944
p.D309V	TCGA-IB-7651	PAAD	TCGA	DEQLDYTVLP	CBL_PTK	0.7785
p.D309V	DO46657	PAAD	ICGC	DEQLDYTVLP	CBL_PTK	0.7785
p.V316A	TCGA-SH-A9CT	MESO	TCGA	DEQLDYTVLP	CBL_PTK	0.5825
p.E308K	DO51948	BLCA	ICGC	DEQLDYTVLP	CBL_PTK	0.3056
p.R328P	DO45330	LUAD	ICGC	DEQLDYTVLP	CBL_PTK	0.0556
p.K315N	DO31664	OV	ICGC	DEQLDYTVLP	CBL_PTK	0.6918
p.D313G	DO232761	PBCA	ICGC	DEQLDYTVLP	CBL_PTK	0.6087
p.T327A	DO41999	UCEC	ICGC	DEQLDYTVLP	CBL_PTK	0.0833
p.R325Q	SIDM00281	Other Solid Cancers	GDSC	DEQLDYTVLP	CBL_PTK	0.1389
p.R325Q	ACH-002100	Skin Cancer	CCLE	DEQLDYTVLP	CBL_PTK	0.1389
p.R325Q	DJM-1	skin	COSMIC	DEQLDYTVLP	CBL_PTK	0.1389
p.D322G	SIDM01045	Endometrial Carcinoma	GDSC	DEQLDYTVLP	CBL_PTK	0.2222
p.D322G	EN	endometrium	COSMIC	DEQLDYTVLP	CBL_PTK	0.2222
p.D307N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DEQLDYTVLP	CBL_PTK	0.2778
p.D307N	ACH-002222	Leukemia	CCLE	DEQLDYTVLP	CBL_PTK	0.2778
p.D307N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DEQLDYTVLP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2D8	X-ray radiation resistance-associated protein 1	CBL_PTK	309:318	DEQLDYTVLP	CBL	0.9704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons