DegronMD - Q6P2D8(XRRA1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E671Q	TCGA-33-4538	LUSC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6744
p.L663V	TCGA-60-2698	LUSC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.2778
p.D322N	TCGA-91-A4BC	LUAD	TCGA	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2222
p.D322N	DO45422	LUAD	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2222
p.K657E	TCGA-AP-A1DK	UCEC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation substituting flanking lysine	0.2222
p.D309H	TCGA-AR-A250	BRCA	TCGA	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.7688
p.Y667H	TCGA-BP-4983	KIRC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6118
p.M304L	TCGA-HU-A4GU	STAD	TCGA	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.1944
p.M304L	DO47849	STAD	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.1944
p.D309V	TCGA-IB-7651	PAAD	TCGA	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.7785
p.D309V	DO46657	PAAD	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.7785
p.Q664E	TCGA-J2-A4AD	LUAD	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.3056
p.V316A	TCGA-SH-A9CT	MESO	TCGA	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.5825
p.E308K	DO51948	BLCA	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.3056
p.R328P	DO45330	LUAD	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.0556
p.K315N	DO31664	OV	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.6918
p.D313G	DO232761	PBCA	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation altering degron motif	0.6087
p.T327A	DO41999	UCEC	ICGC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.0833
p.R325Q	SIDM00281	Other Solid Cancers	GDSC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.1389
p.R325Q	ACH-002100	Skin Cancer	CCLE	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.1389
p.R325Q	DJM-1	skin	COSMIC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.1389
p.D322G	SIDM01045	Endometrial Carcinoma	GDSC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2222
p.D322G	EN	endometrium	COSMIC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2222
p.D307N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2778
p.D307N	ACH-002222	Leukemia	CCLE	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2778
p.D307N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DEQLDYTVLP	CBL_PTK	309:318	Mutation rewiring degron network	0.2778
p.P678L	SIDM01770	Gastric Carcinoma	GDSC	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1389
p.P678L	ACH-000908	Gastric Cancer	CCLE	KPYVHKE	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XRRA1

UniProt ID: Q6P2D8

Entrez ID: 143570

Protein name: X-ray radiation resistance-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XRRA1 in