DegronMD

Uniprot ID: Q6P2D8

Source protein: X-ray radiation resistance-associated protein 1

Source gene: XRRA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 665:671

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 107.2571

COIL: 0.7771

CONS_SCORE: 0.4221

DSS_SCORE: 0.5864

HELIX: 0.1903

FCONS_SCORE: 1.1899

RIG_SCORE: 0.7418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E671Q	TCGA-33-4538	LUSC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.6744
p.L663V	TCGA-60-2698	LUSC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K657E	TCGA-AP-A1DK	UCEC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y667H	TCGA-BP-4983	KIRC	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Q664E	TCGA-J2-A4AD	LUAD	TCGA	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P678L	SIDM01770	Gastric Carcinoma	GDSC	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P678L	ACH-000908	Gastric Cancer	CCLE	KPYVHKE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2D8	X-ray radiation resistance-associated protein 1	LIG_APCC_ABBAyCdc20_2	665:671	KPYVHKE	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons