DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_COP1_1

Location: 263:274

E3 ligase: COP1

DEGRON score: 0.9818

ASA_SCORE: 78.9167

COIL: 0.7273

CONS_SCORE: 0.3072

DSS_SCORE: 0.3877

HELIX: 0.2078

FCONS_SCORE: 0.8322

RIG_SCORE: 0.7823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R265W	TCGA-AA-3864	COAD	TCGA	DERATLLNVPDL	DEG_COP1_1	0.7523
p.R265W	DO8490	COAD	ICGC	DERATLLNVPDL	DEG_COP1_1	0.7523
p.R265W	DO227549	COCA	ICGC	DERATLLNVPDL	DEG_COP1_1	0.7523
p.G254C	TCGA-AX-A063	UCEC	TCGA	DERATLLNVPDL	DEG_COP1_1	0.0833
p.G254C	DO42201	UCEC	ICGC	DERATLLNVPDL	DEG_COP1_1	0.0833
p.P272L	DO225337	BRCA	ICGC	DERATLLNVPDL	DEG_COP1_1	0.7582
p.N282D	DO233871	GACA	ICGC	DERATLLNVPDL	DEG_COP1_1	0.1111
p.S284T	DO231742	LINC	ICGC	DERATLLNVPDL	DEG_COP1_1	0.5
p.L269S	DO229479	SKCA	ICGC	DERATLLNVPDL	DEG_COP1_1	0.6556
p.D273H	SIDM00621	Ewing's Sarcoma	GDSC	DERATLLNVPDL	DEG_COP1_1	0.7688
p.D273H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	0.7688
p.R269W	ACH-001184	Sarcoma	CCLE	DERATLLNVPDL	DEG_COP1_1	0.8634
p.D277H	ACH-002113	Bone Cancer	CCLE	DERATLLNVPDL	DEG_COP1_1	0.6944
p.D277H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	0.6944
p.D261H	EW-13	bone	COSMIC	DERATLLNVPDL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	DEG_COP1_1	263:274	DERATLLNVPDL	COP1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons