DegronMD

Uniprot ID: Q5FBB7

Source protein: Shugoshin 1

Source gene: SGO1

Class: DEG_Kelch_Keap1_1

Location: 172:177

E3 ligase: KEAP1

DEGRON score: 0.9973

ASA_SCORE: 80.85

COIL: 0.7227

CONS_SCORE: 0.4492

DSS_SCORE: 0.5436

HELIX: 0.1107

FCONS_SCORE: 1.0963

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G176D	SIDM02041	Colorectal Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.7198
p.D172Y	SIDM00818	Kidney Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.7325
p.D172Y	RCC-JF	kidney	COSMIC	DFDSGE	DEG_Kelch_Keap1_1	0.7325
p.T181A	SIDM01162	Kidney Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.2222
p.T181A	SW156	kidney	COSMIC	DFDSGE	DEG_Kelch_Keap1_1	0.2222
p.V171A	SIDM00879	Breast Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.3056
p.V171A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.3056
p.V171A	SIDM00785	Acute Myeloid Leukemia	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.3056
p.V171A	SIDM01664	Prostate Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.3056
p.V171A	SIDM01387	Small Cell Lung Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FBB7	Shugoshin 1	DEG_Kelch_Keap1_1	172:177	DFDSGE	KEAP1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons