DegronMD - Q5FBB7(SGO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G176D	SIDM02041	Colorectal Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.7198
p.G176D	SIDM02041	Colorectal Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation altering degron motif	0.7198
p.Q322P	SIDM01292	Esophageal Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00845	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00656	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00854	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00487	Colorectal Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00793	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM00641	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM01608	Endometrial Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Q322P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.0833
p.Y309C	SIDM00969	Ovarian Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation altering degron motif	0.5976
p.Y309C	SIDM00694	Other Solid Cancers	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation altering degron motif	0.5976
p.Y309C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation altering degron motif	0.5976
p.P321S	SIDM01240	Melanoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.1111
p.P321S	SIDM01322	Oral Cavity Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation rewiring degron network	0.1111
p.D172Y	SIDM00818	Kidney Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.7325
p.D172Y	RCC-JF	kidney	COSMIC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation altering degron motif	0.7325
p.T181A	SIDM01162	Kidney Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.2222
p.T181A	SIDM01162	Kidney Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.3056
p.T181A	SW156	kidney	COSMIC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.2222
p.T181A	SW156	kidney	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.3056
p.S180P	SIDM00878	Breast Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation altering degron motif	0.6752
p.S180P	HCC1569	breast	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation altering degron motif	0.6752
p.V171A	SIDM00879	Breast Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.3056
p.V171A	SIDM00879	Breast Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.25
p.V171A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.3056
p.V171A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.25
p.V171A	SIDM00785	Acute Myeloid Leukemia	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.3056
p.V171A	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.25
p.V171A	SIDM01664	Prostate Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.3056
p.V171A	SIDM01664	Prostate Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.25
p.V171A	SIDM01387	Small Cell Lung Carcinoma	GDSC	DFDSGE	DEG_Kelch_Keap1_1	172:177	Mutation rewiring degron network	0.3056
p.V171A	SIDM01387	Small Cell Lung Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation rewiring degron network	0.25
p.S180F	SIDM01100	Neuroblastoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation altering degron motif	0.7982
p.E179Q	UMC-11	lung	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	174:180	Mutation altering degron motif	0.6744
p.L302R	HCC2998	large intestine	COSMIC	YKENK	DEG_APCC_KENBOX_2	309:313	Mutation substituting flanking lysine	0.25

Kaplan plot for SGO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGO1

UniProt ID: Q5FBB7

Entrez ID: 151648

Protein name: Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGO1 in