DegronMD

Uniprot ID: Q5FBB7

Source protein: Shugoshin 1

Source gene: SGO1

Class: DEG_SCF_TRCP1_1

Location: 174:180

E3 ligase: BTRC

DEGRON score: 0.8574

ASA_SCORE: 84.2286

COIL: 0.754

CONS_SCORE: 0.4574

DSS_SCORE: 0.4919

HELIX: 0.1267

FCONS_SCORE: 1.0126

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G176D	SIDM02041	Colorectal Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.7198
p.T181A	SIDM01162	Kidney Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.3056
p.T181A	SW156	kidney	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	0.3056
p.S180P	SIDM00878	Breast Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.6752
p.S180P	HCC1569	breast	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	0.6752
p.V171A	SIDM00879	Breast Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.25
p.V171A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.25
p.V171A	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.25
p.V171A	SIDM01664	Prostate Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.25
p.V171A	SIDM01387	Small Cell Lung Carcinoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.25
p.S180F	SIDM01100	Neuroblastoma	GDSC	DSGEAKS	DEG_SCF_TRCP1_1	0.7982
p.E179Q	UMC-11	lung	COSMIC	DSGEAKS	DEG_SCF_TRCP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FBB7	Shugoshin 1	DEG_SCF_TRCP1_1	174:180	DSGEAKS	BTRC	0.8574	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons