DegronMD

Uniprot ID: Q5FBB7

Source protein: Shugoshin 1

Source gene: SGO1

Class: DEG_APCC_KENBOX_2

Location: 309:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 137.44

COIL: 0.751

CONS_SCORE: 0.5772

DSS_SCORE: 0.7701

HELIX: 0.246

FCONS_SCORE: 1.228

RIG_SCORE: 0.6375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q322P	SIDM01292	Esophageal Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00845	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00656	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00854	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00487	Colorectal Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00793	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM00641	Burkitt's Lymphoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM01608	Endometrial Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Q322P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.0833
p.Y309C	SIDM00969	Ovarian Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.5976
p.Y309C	SIDM00694	Other Solid Cancers	GDSC	YKENK	DEG_APCC_KENBOX_2	0.5976
p.Y309C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	YKENK	DEG_APCC_KENBOX_2	0.5976
p.P321S	SIDM01240	Melanoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.1111
p.P321S	SIDM01322	Oral Cavity Carcinoma	GDSC	YKENK	DEG_APCC_KENBOX_2	0.1111
p.L302R	HCC2998	large_intestine	COSMIC	YKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FBB7	Shugoshin 1	DEG_APCC_KENBOX_2	309:313	YKENK	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons