DegronMD

Uniprot ID: Q8NFF2

Source protein: Sodium/potassium/calcium exchanger 4

Source gene: SLC24A4

Class: DEG_COP1_1

Location: 410:420

E3 ligase: COP1

DEGRON score: 0.9275

ASA_SCORE: 63.5455

COIL: 0.7775

CONS_SCORE: 0.2999

DSS_SCORE: 0.4681

HELIX: 0.1815

FCONS_SCORE: 0.9912

RIG_SCORE: 0.7309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V417M	TCGA-51-4081	LUSC	TCGA	DFLSPFSVPEA	DEG_COP1_1	0.7208
p.V407M	TCGA-AX-A1C4	UCEC	TCGA	DFLSPFSVPEA	DEG_COP1_1	0.25
p.V428A	TCGA-B5-A3FC	UCEC	TCGA	DFLSPFSVPEA	DEG_COP1_1	0.1111
p.E405V	TCGA-BR-8591	STAD	TCGA	DFLSPFSVPEA	DEG_COP1_1	0.1944
p.R421T	TCGA-UY-A9PD	BLCA	TCGA	DFLSPFSVPEA	DEG_COP1_1	0.3056
p.G415R	DO9226	COAD	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.7568
p.G415R	DO13462	GBM	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.7568
p.P421L	DO234336	ESAD	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.3056
p.V408E	DO48204	ESCA	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.2778
p.P421Q	DO14766	HNSC	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.3056
p.P421Q	DO47573	SKCM	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.3056
p.M425I	DO229026	LICA	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.1944
p.V411M	DO26790	LUSC	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.7208
p.V411M	DO222708	MELA	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.7208
p.G419V	DO37571	SKCM	ICGC	DFLSPFSVPEA	DEG_COP1_1	0.7532
p.P402S	SIDM00498	Colorectal Carcinoma	GDSC	DFLSPFSVPEA	DEG_COP1_1	0.1111
p.P402S	SNU-C5	large_intestine	COSMIC	DFLSPFSVPEA	DEG_COP1_1	0.1111
p.G419A	NCI-H345	lung	COSMIC	DFLSPFSVPEA	DEG_COP1_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFF2	Sodium/potassium/calcium exchanger 4	DEG_COP1_1	410:420	DFLSPFSVPEA	COP1	0.9275	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons