DegronMD - Q8NFF2(SLC24A4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V417M	TCGA-51-4081	LUSC	TCGA	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7208
p.A2V	TCGA-AA-3877	COAD	TCGA	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.A2V	DO7855	COAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.V407M	TCGA-AX-A1C4	UCEC	TCGA	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.25
p.R8Q	TCGA-AZ-6598	COAD	TCGA	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6218
p.R8Q	DO10276	COAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6218
p.R8Q	DO233855	GACA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6218
p.V428A	TCGA-B5-A3FC	UCEC	TCGA	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.E405V	TCGA-BR-8591	STAD	TCGA	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1944
p.R421T	TCGA-UY-A9PD	BLCA	TCGA	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.3056
p.T6I	DO575	BLCA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7078
p.R13L	DO225154	BRCA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.2778
p.G415R	DO9226	COAD	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7568
p.G415R	DO13462	GBM	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7568
p.P421L	DO234336	ESAD	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.3056
p.V408E	DO48204	ESCA	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.2778
p.P421Q	DO14766	HNSC	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.3056
p.P421Q	DO47573	SKCM	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.3056
p.G5V	DO229024	LICA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6421
p.M425I	DO229026	LICA	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1944
p.V411M	DO26790	LUSC	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7208
p.V411M	DO222708	MELA	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7208
p.G419V	DO37571	SKCM	ICGC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.7532
p.A17V	DO38185	STAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.P402S	SIDM00498	Colorectal Carcinoma	GDSC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.P402S	SNU-C5	large intestine	COSMIC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation rewiring degron network	0.1111
p.G419A	NCI-H345	lung	COSMIC	DFLSPFSVPEA	DEG_COP1_1	410:420	Mutation altering degron motif	0.754

Kaplan plot for SLC24A4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC24A4

UniProt ID: Q8NFF2

Entrez ID: 123041

Protein name: Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC24A4 in