DegronMD

Uniprot ID: Q8NFF2

Source protein: Sodium/potassium/calcium exchanger 4

Source gene: SLC24A4

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8299

ASA_SCORE: 114.4889

COIL: 0.8616

CONS_SCORE: 0.2103

DSS_SCORE: 0.4776

HELIX: 0.0908

FCONS_SCORE: 0.9112

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2V	TCGA-AA-3877	COAD	TCGA	LRGTLRPLK	DEG_APCC_DBOX_1	0.3056
p.A2V	DO7855	COAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.3056
p.R8Q	TCGA-AZ-6598	COAD	TCGA	LRGTLRPLK	DEG_APCC_DBOX_1	0.6218
p.R8Q	DO10276	COAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.6218
p.R8Q	DO233855	GACA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.6218
p.T6I	DO575	BLCA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.7078
p.R13L	DO225154	BRCA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.2778
p.G5V	DO229024	LICA	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.6421
p.A17V	DO38185	STAD	ICGC	LRGTLRPLK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFF2	Sodium/potassium/calcium exchanger 4	DEG_APCC_DBOX_1	3:11	LRGTLRPLK	APC,CDC20,FZR1	0.8299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons