DegronMD

Uniprot ID: Q8IVF4

Source protein: Dynein axonemal heavy chain 10

Source gene: DNAH10

Class: DEG_Kelch_Keap1_1

Location: 1606:1611

E3 ligase: KEAP1

DEGRON score: 0.8344

ASA_SCORE: 76.4667

COIL: 0.813

CONS_SCORE: 0.2813

DSS_SCORE: 0.2223

HELIX: 0.0395

FCONS_SCORE: 0.5784

RIG_SCORE: 0.7009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1610R	TCGA-18-3409	LUSC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.7568
p.G1610R	DO26444	LUSC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.7568
p.N1598S	TCGA-A5-A1OF	UCEC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.1111
p.N1598S	DO42568	UCEC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.1111
p.M1617I	TCGA-AG-A002	READ	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.1667
p.M1617I	TCGA-EE-A3AC	SKCM	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.1667
p.M1617I	DO37631	SKCM	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.1667
p.G1607S	TCGA-D1-A16X	UCEC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.5882
p.G1607S	DO41799	UCEC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.5882
p.D1597N	TCGA-FW-A3R5	SKCM	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.D1597N	DO37406	SKCM	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.G1607D	TCGA-QC-A7B5	SARC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.6087
p.G1607D	DO220239	SARC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.6087
p.D1608Y	TCGA-S9-A6TS	LGG	TCGA	DGDSGE	DEG_Kelch_Keap1_1	0.7325
p.D1608Y	DO50181	LGG	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.7325
p.S1601P	DO230336	COCA	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.6389
p.A1620T	DO233882	GACA	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.A1620T	SIDM00596	Endometrial Carcinoma	GDSC	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.A1620T	ACH-001517	Endometrial/Uterine Cancer	CCLE	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.A1620T	HEC-1	endometrium	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.0833
p.Y1596F	DO231049	LUSC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	0.5
p.I1599V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DGDSGE	DEG_Kelch_Keap1_1	0.1389
p.I1599V	ACH-002256	Leukemia	CCLE	DGDSGE	DEG_Kelch_Keap1_1	0.1389
p.I1599V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.1389
p.V1614L	SIDM00927	Small Cell Lung Carcinoma	GDSC	DGDSGE	DEG_Kelch_Keap1_1	0.25
p.V1614L	ACH-000871	Lung Cancer	CCLE	DGDSGE	DEG_Kelch_Keap1_1	0.25
p.V1614L	NCI-H510A	lung	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.25
p.S1621L	Sarc9371	bone	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.0556
p.S1621L	KYSE-180	oesophagus	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.0556
p.E1606K	LU-165	lung	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGDSGE

Degron related mutations and impact score

Drug responses associated with DNAH10 mutations

All proteins holding degron of DGDSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF4	Dynein axonemal heavy chain 10	DEG_Kelch_Keap1_1	1606:1611	DGDSGE	KEAP1	0.8344	More...