DegronMD - Q8IVF4(DNAH10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1610R	TCGA-18-3409	LUSC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.7568
p.G1610R	DO26444	LUSC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.7568
p.N1598S	TCGA-A5-A1OF	UCEC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1111
p.N1598S	DO42568	UCEC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1111
p.R1482I	TCGA-AG-A002	READ	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.8102
p.M1617I	TCGA-AG-A002	READ	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1667
p.M1617I	TCGA-EE-A3AC	SKCM	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1667
p.M1617I	DO37631	SKCM	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1667
p.G1607S	TCGA-D1-A16X	UCEC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.5882
p.G1607S	DO41799	UCEC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.5882
p.I1476M	TCGA-E6-A1LX	UCEC	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation rewiring degron network	0.1667
p.I1476M	DO41020	UCEC	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation rewiring degron network	0.1667
p.W1484L	TCGA-EO-A3B0	UCEC	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.5904
p.W1484L	DO219773	UCEC	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.5904
p.W1484L	SIDM00534	Colorectal Carcinoma	GDSC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.5904
p.W1484L	ACH-000986	Colon/Colorectal Cancer	CCLE	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.5904
p.W1484L	HT-115	large intestine	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.5904
p.Y1486H	TCGA-ER-A19E	SKCM	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.6118
p.Y1486H	DO47542	SKCM	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.6118
p.D1597N	TCGA-FW-A3R5	SKCM	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.D1597N	DO37406	SKCM	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.R1482K	TCGA-GN-A266	SKCM	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.6126
p.R1482K	DO37432	SKCM	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.6126
p.G1607D	TCGA-QC-A7B5	SARC	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.6087
p.G1607D	DO220239	SARC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.6087
p.D1608Y	TCGA-S9-A6TS	LGG	TCGA	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.7325
p.D1608Y	DO50181	LGG	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.7325
p.S1601P	DO230336	COCA	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation blocking phosphorylation signal	0.6389
p.A1620T	DO233882	GACA	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.A1620T	SIDM00596	Endometrial Carcinoma	GDSC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.A1620T	ACH-001517	Endometrial/Uterine Cancer	CCLE	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.A1620T	HEC-1	endometrium	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0833
p.Y1596F	DO231049	LUSC	ICGC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation blocking phosphorylation signal	0.5
p.I1599V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1389
p.I1599V	ACH-002256	Leukemia	CCLE	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1389
p.I1599V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.1389
p.V1614L	SIDM00927	Small Cell Lung Carcinoma	GDSC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.25
p.V1614L	ACH-000871	Lung Cancer	CCLE	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.25
p.V1614L	NCI-H510A	lung	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.25
p.E1483A	H4	central nervous system	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation altering degron motif	0.7701
p.S1621L	Sarc9371	bone	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0556
p.S1621L	KYSE-180	oesophagus	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation rewiring degron network	0.0556
p.E1493K	HT-115	large intestine	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation rewiring degron network	0.1944
p.E1606K	LU-165	lung	COSMIC	DGDSGE	DEG_Kelch_Keap1_1	1606:1611	Mutation altering degron motif	0.7022
p.K1476R	FLO-1	oesophagus	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	1482:1488	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH10

UniProt ID: Q8IVF4

Entrez ID: 196385

Protein name: Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH10 in