DegronMD

Uniprot ID: Q8IVF4

Source protein: Dynein axonemal heavy chain 10

Source gene: DNAH10

Class: LIG_APCC_ABBAyCdc20_2

Location: 1482:1488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.907

ASA_SCORE: 54.2571

COIL: 0.1979

CONS_SCORE: 0.628

DSS_SCORE: 0.0068

HELIX: 0.79

FCONS_SCORE: 1.1974

RIG_SCORE: 0.9938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1482I	TCGA-AG-A002	READ	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.8102
p.I1476M	TCGA-E6-A1LX	UCEC	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.I1476M	DO41020	UCEC	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.W1484L	TCGA-EO-A3B0	UCEC	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.5904
p.W1484L	DO219773	UCEC	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.5904
p.W1484L	SIDM00534	Colorectal Carcinoma	GDSC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.5904
p.W1484L	ACH-000986	Colon/Colorectal Cancer	CCLE	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.5904
p.W1484L	HT-115	large_intestine	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.5904
p.Y1486H	TCGA-ER-A19E	SKCM	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y1486H	DO47542	SKCM	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.6118
p.R1482K	TCGA-GN-A266	SKCM	TCGA	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R1482K	DO37432	SKCM	ICGC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.E1483A	H4	central_nervous_system	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.7701
p.E1493K	HT-115	large_intestine	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K1476R	FLO-1	oesophagus	COSMIC	RKWMYLE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF4	Dynein axonemal heavy chain 10	LIG_APCC_ABBAyCdc20_2	1482:1488	RKWMYLE	APC,CDC20,FZR1	0.907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons