DegronMD

Uniprot ID: Q8N6R0

Source protein: eEF1A lysine and N-terminal methyltransferase

Source gene: METTL13

Class: DEG_Kelch_Keap1_1

Location: 274:279

E3 ligase: KEAP1

DEGRON score: 0.8298

ASA_SCORE: 66.35

COIL: 0.9028

CONS_SCORE: 0.2745

DSS_SCORE: 0.2712

HELIX: 0.036

FCONS_SCORE: 0.8815

RIG_SCORE: 0.6854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S289N	SIDM00845	Burkitt's Lymphoma	GDSC	DGDTGE	DEG_Kelch_Keap1_1	0.5
p.G279A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	0.754
p.R271G	SKN	soft_tissue	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	0.25
p.A276S	NCI-H510A	lung	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6R0	eEF1A lysine and N-terminal methyltransferase	DEG_Kelch_Keap1_1	274:279	DGDTGE	KEAP1	0.8298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons