DegronMD - Q8N6R0(METTL13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S289N	SIDM00845	Burkitt's Lymphoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation blocking phosphorylation signal	0.75
p.S289N	SIDM00845	Burkitt's Lymphoma	GDSC	DGDTGE	DEG_Kelch_Keap1_1	274:279	Mutation blocking phosphorylation signal	0.5
p.T291A	SIDM00845	Burkitt's Lymphoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.25
p.R357G	SIDM00377	Other Sarcomas	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation rewiring degron network	0.2222
p.R357G	SKN	soft tissue	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation rewiring degron network	0.2222
p.G365A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.6429
p.G365A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.6429
p.R296W	SIDM00899	Pancreatic Carcinoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111
p.R296W	SIDM00963	Breast Carcinoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111
p.R296W	AsPC-1	pancreas	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111
p.R296W	BT-474	breast	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111
p.A362S	SIDM00927	Small Cell Lung Carcinoma	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.7588
p.A362S	NCI-H510A	lung	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.7588
p.R296Q	SIDM00379	Glioma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1111
p.R384W	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation rewiring degron network	0.0556
p.G279A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	274:279	Mutation altering degron motif	0.754
p.A297V	639-V	urinary tract	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0833
p.R271G	SKN	soft tissue	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0833
p.R271G	SKN	soft tissue	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	274:279	Mutation rewiring degron network	0.25
p.A367V	639-V	urinary tract	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.6936
p.H358Q	NTERA-2_cl_D1	testis	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation rewiring degron network	0.25
p.P364L	SNU-1040	large intestine	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	361:374	Mutation altering degron motif	0.7582
p.P294L	SNU-1040	large intestine	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.A276S	NCI-H510A	lung	COSMIC	DGDTGE	DEG_Kelch_Keap1_1	274:279	Mutation altering degron motif	0.7588

Kaplan plot for METTL13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

METTL13

UniProt ID: Q8N6R0

Entrez ID: 51603

Protein name: eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for METTL13 in