DegronMD

Uniprot ID: Q8N6R0

Source protein: eEF1A lysine and N-terminal methyltransferase

Source gene: METTL13

Class: DEG_ODPH_VHL_1

Location: 361:374

E3 ligase: VHL

DEGRON score: 0.9734

ASA_SCORE: 57.1071

COIL: 0.7464

CONS_SCORE: 0.3154

DSS_SCORE: 0.4054

HELIX: 0.104

FCONS_SCORE: 0.8888

RIG_SCORE: 0.733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R357G	SIDM00377	Other Sarcomas	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.2222
p.R357G	SKN	soft_tissue	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.2222
p.G365A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.6429
p.G365A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.6429
p.A362S	SIDM00927	Small Cell Lung Carcinoma	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.7588
p.A362S	NCI-H510A	lung	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.7588
p.R384W	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.0556
p.A367V	639-V	urinary_tract	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.6936
p.H358Q	NTERA-2_cl_D1	testis	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.25
p.P364L	SNU-1040	large_intestine	COSMIC	LAPAGMPTQQQVPF	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6R0	eEF1A lysine and N-terminal methyltransferase	DEG_ODPH_VHL_1	361:374	LAPAGMPTQQQVPF	VHL	0.9734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons