DegronMD

Uniprot ID: Q8N6R0

Source protein: eEF1A lysine and N-terminal methyltransferase

Source gene: METTL13

Class: DEG_APCC_DBOX_1

Location: 280:288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8774

ASA_SCORE: 24.6333

COIL: 0.1826

CONS_SCORE: 0.3601

DSS_SCORE: 0.4219

HELIX: 0.007

FCONS_SCORE: 1.2799

RIG_SCORE: 0.7769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S289N	SIDM00845	Burkitt's Lymphoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	0.75
p.T291A	SIDM00845	Burkitt's Lymphoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	0.25
p.R296W	SIDM00899	Pancreatic Carcinoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1111
p.R296W	SIDM00963	Breast Carcinoma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1111
p.R296W	AsPC-1	pancreas	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1111
p.R296W	BT-474	breast	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1111
p.R296Q	SIDM00379	Glioma	GDSC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1111
p.A297V	639-V	urinary_tract	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	0.0833
p.R271G	SKN	soft_tissue	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	0.0833
p.P294L	SNU-1040	large_intestine	COSMIC	PRYTLHVVD	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6R0	eEF1A lysine and N-terminal methyltransferase	DEG_APCC_DBOX_1	280:288	PRYTLHVVD	APC,CDC20,FZR1	0.8774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons