DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DGKRNMYTAHP
Uniprot ID:
Q9HCK5
Source protein:
Protein argonaute-4
Source gene:
AGO4
Class:
CBL_PTK
Location:
85:95
E3 ligase:
CBL
DEGRON score:
0.6189
ASA_SCORE:
38
COIL:
0.4233
CONS_SCORE:
0.5244
DSS_SCORE:
0.5028
HELIX:
0.0274
FCONS_SCORE:
1.4001
RIG_SCORE:
0.7247
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R80W
TCGA-AP-A1DV
UCEC
TCGA
DGKRNMYTAHP
CBL_PTK
0.1944
p.R80W
DO43186
UCEC
ICGC
DGKRNMYTAHP
CBL_PTK
0.1944
p.R102S
TCGA-AX-A1CE
UCEC
TCGA
DGKRNMYTAHP
CBL_PTK
0.1389
p.R102S
DO42280
UCEC
ICGC
DGKRNMYTAHP
CBL_PTK
0.1389
p.R100W
TCGA-AX-A2HC
UCEC
TCGA
DGKRNMYTAHP
CBL_PTK
0.1944
p.R100W
DO41572
UCEC
ICGC
DGKRNMYTAHP
CBL_PTK
0.1944
p.R102M
TCGA-AX-A2HJ
UCEC
TCGA
DGKRNMYTAHP
CBL_PTK
0.1389
p.R102M
DO42105
UCEC
ICGC
DGKRNMYTAHP
CBL_PTK
0.1389
p.M105V
TCGA-LN-A4A5
ESCA
TCGA
DGKRNMYTAHP
CBL_PTK
0.0556
p.D79Y
TCGA-NC-A5HN
LUSC
TCGA
DGKRNMYTAHP
CBL_PTK
0.1667
p.D79Y
DO52025
LUSC
ICGC
DGKRNMYTAHP
CBL_PTK
0.1667
p.M90I
DO223886
AML
ICGC
DGKRNMYTAHP
CBL_PTK
0.6507
p.R100Q
DO222955
BTCA
ICGC
DGKRNMYTAHP
CBL_PTK
0.1944
p.D101V
DO223579
CLLE
ICGC
DGKRNMYTAHP
CBL_PTK
0.1667
p.R100L
DO228976
LICA
ICGC
DGKRNMYTAHP
CBL_PTK
0.1944
p.D104Y
DO229015
LICA
ICGC
DGKRNMYTAHP
CBL_PTK
0.0833
Drug responses associated with AGO4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGKRNMYTAHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCK5
Protein argonaute-4
CBL_PTK
85:95
DGKRNMYTAHP
CBL
0.6189
More...
