DegronMD - Q9HCK5(AGO4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R17C	TCGA-85-8352	LUSC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.719
p.R17C	TCGA-E7-A7DV	BLCA	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.719
p.R17C	DO48583	BLCA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.719
p.R17C	DO45540	LUSC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.719
p.R80W	TCGA-AP-A1DV	UCEC	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.R80W	DO43186	UCEC	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.R17H	TCGA-AX-A05S	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.7133
p.R17H	DO43218	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.7133
p.R102S	TCGA-AX-A1CE	UCEC	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1389
p.R102S	DO42280	UCEC	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1389
p.P384T	TCGA-AX-A1CE	UCEC	TCGA	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.1389
p.P384T	DO42280	UCEC	ICGC	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.1389
p.R100W	TCGA-AX-A2HC	UCEC	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.R100W	DO41572	UCEC	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.R102M	TCGA-AX-A2HJ	UCEC	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1389
p.R102M	DO42105	UCEC	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1389
p.R18H	TCGA-B5-A0JU	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8244
p.R18H	DO229052	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8244
p.R18H	DO40819	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8244
p.H34N	TCGA-B5-A1MR	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.H34N	DO41758	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.P9L	TCGA-CM-6171	COAD	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1111
p.P9L	DO8151	COAD	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1111
p.E388K	TCGA-E2-A1LB	BRCA	TCGA	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.25
p.E388K	DO4461	BRCA	ICGC	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.25
p.R18C	TCGA-EE-A2GC	SKCM	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8301
p.R18C	TCGA-EE-A2MR	SKCM	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8301
p.R18C	DO37839	SKCM	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8301
p.R18C	DO37819	SKCM	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8301
p.M105V	TCGA-LN-A4A5	ESCA	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.0556
p.D79Y	TCGA-NC-A5HN	LUSC	TCGA	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1667
p.D79Y	DO52025	LUSC	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1667
p.P8S	TCGA-VS-A8EK	CESC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.P8S	DO51623	CESC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.M90I	DO223886	AML	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation altering degron motif	0.6507
p.E399D	DO48440	BLCA	ICGC	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.25
p.S11T	DO1092	BRCA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.6111
p.R100Q	DO222955	BTCA	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.D101V	DO223579	CLLE	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1667
p.V404L	DO234360	ESAD	ICGC	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.1111
p.L30P	DO228542	GACA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.R403M	DO233908	GACA	ICGC	IVVHNE	LIG_APCC_ABBA_1	391:396	Mutation rewiring degron network	0.1389
p.A32S	DO228976	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1389
p.A32S	DO229034	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1389
p.R100L	DO228976	LICA	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.1944
p.D104Y	DO229015	LICA	ICGC	DGKRNMYTAHP	CBL_PTK	85:95	Mutation rewiring degron network	0.0833
p.R17L	DO229027	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.7316
p.V24F	DO229036	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.7068

Kaplan plot for AGO4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGO4

UniProt ID: Q9HCK5

Entrez ID: 192670

Protein name: Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGO4 in