DegronMD

Uniprot ID: Q9HCK5

Source protein: Protein argonaute-4

Source gene: AGO4

Class: LIG_APCC_ABBA_1

Location: 391:396

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6648

ASA_SCORE: 75.35

COIL: 0.6362

CONS_SCORE: 0.4695

DSS_SCORE: 0.2616

HELIX: 0.004

FCONS_SCORE: 0.8829

RIG_SCORE: 0.8363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P384T	TCGA-AX-A1CE	UCEC	TCGA	IVVHNE	LIG_APCC_ABBA_1	0.1389
p.P384T	DO42280	UCEC	ICGC	IVVHNE	LIG_APCC_ABBA_1	0.1389
p.E388K	TCGA-E2-A1LB	BRCA	TCGA	IVVHNE	LIG_APCC_ABBA_1	0.25
p.E388K	DO4461	BRCA	ICGC	IVVHNE	LIG_APCC_ABBA_1	0.25
p.E399D	DO48440	BLCA	ICGC	IVVHNE	LIG_APCC_ABBA_1	0.25
p.V404L	DO234360	ESAD	ICGC	IVVHNE	LIG_APCC_ABBA_1	0.1111
p.R403M	DO233908	GACA	ICGC	IVVHNE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK5	Protein argonaute-4	LIG_APCC_ABBA_1	391:396	IVVHNE	APC,CDC20,FZR1	0.6648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons