DegronMD

Uniprot ID: Q9HCK5

Source protein: Protein argonaute-4

Source gene: AGO4

Class: DEG_APCC_DBOX_1

Location: 17:25

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 74.1556

COIL: 0.8309

CONS_SCORE: 0.5621

DSS_SCORE: 0.484

HELIX: 0.0209

FCONS_SCORE: 1.3358

RIG_SCORE: 0.6573

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R18C	TCGA-EE-A2GC	SKCM	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.8301
p.R18C	TCGA-EE-A2MR	SKCM	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.8301
p.R18C	DO37839	SKCM	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.8301
p.R18C	DO37819	SKCM	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.8301
p.R18H	TCGA-B5-A0JU	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.8244
p.R18H	DO229052	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.8244
p.R18H	DO40819	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.8244
p.R17L	DO229027	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.7316
p.R17C	TCGA-85-8352	LUSC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.719
p.R17C	TCGA-E7-A7DV	BLCA	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.719
p.R17C	DO48583	BLCA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.719
p.R17C	DO45540	LUSC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.719
p.R17H	TCGA-AX-A05S	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.7133
p.R17H	DO43218	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.7133
p.V24F	DO229036	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.7068
p.S11T	DO1092	BRCA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.6111
p.L30P	DO228542	GACA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.1944
p.A32S	DO228976	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.1389
p.A32S	DO229034	LICA	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.1389
p.P9L	TCGA-CM-6171	COAD	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.1111
p.P9L	DO8151	COAD	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.1111
p.H34N	TCGA-B5-A1MR	UCEC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.0833
p.H34N	DO41758	UCEC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.0833
p.P8S	TCGA-VS-A8EK	CESC	TCGA	RRPGLGTVG	DEG_APCC_DBOX_1	0.0833
p.P8S	DO51623	CESC	ICGC	RRPGLGTVG	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK5	Protein argonaute-4	DEG_APCC_DBOX_1	17:25	RRPGLGTVG	APC,CDC20,FZR1	0.9946	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons