DegronMD

Uniprot ID: Q9BVL4

Source protein: Protein adenylyltransferase SelO, mitochondrial

Source gene: SELENOO

Class: CBL_PTK

Location: 646:656

E3 ligase: CBL

DEGRON score: 0.9856

ASA_SCORE: 72.7182

COIL: 0.8153

CONS_SCORE: 0.4918

DSS_SCORE: 0.5112

HELIX: 0.1119

FCONS_SCORE: 0.966

RIG_SCORE: 0.6689

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E638K	SIDM01265	Plasma Cell Myeloma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00683	Prostate Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM01090	Colorectal Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00969	Ovarian Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00087	Plasma Cell Myeloma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00654	Small Cell Lung Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00844	Burkitt's Lymphoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00793	Burkitt's Lymphoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM01133	Other Solid Cancers	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00720	Mesothelioma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM00808	Burkitt's Lymphoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.E638K	SIDM01254	Burkitt's Lymphoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.1111
p.V665M	SIDM00338	Acute Myeloid Leukemia	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00193	Colorectal Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00573	Glioblastoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00013	Melanoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00492	Glioblastoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00612	Glioma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM01577	Plasma Cell Myeloma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM00163	Biliary Tract Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM01446	Glioblastoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM01378	Ovarian Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	SIDM01559	Melanoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	KINGS-1	central_nervous_system	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	TE-11	oesophagus	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	no-11	central_nervous_system	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	KYSE-410	oesophagus	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.V665M	AM-38	central_nervous_system	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.P657L	SIDM00693	Bladder Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.3056
p.P657L	SIDM01732	Non-Cancerous	GDSC	DGRQRSYSSKP	CBL_PTK	0.3056
p.A637T	SIDM00890	Melanoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.0833
p.A637T	C32	skin	COSMIC	DGRQRSYSSKP	CBL_PTK	0.0833
p.G644R	SIDM01608	Endometrial Carcinoma	GDSC	DGRQRSYSSKP	CBL_PTK	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGRQRSYSSKP

Degron related mutations and impact score

Drug responses associated with SELENOO mutations

All proteins holding degron of DGRQRSYSSKP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVL4	Protein adenylyltransferase SelO, mitochondrial	CBL_PTK	646:656	DGRQRSYSSKP	CBL	0.9856	More...