DegronMD

Uniprot ID: P04217

Source protein: Alpha-1B-glycoprotein

Source gene: A1BG

Class: DEG_COP1_1

Location: 155:164

E3 ligase: COP1

DEGRON score: 0.7563

ASA_SCORE: 88.3

COIL: 0.7897

CONS_SCORE: 0.4937

DSS_SCORE: 0.4108

HELIX: 0.0783

FCONS_SCORE: 0.8255

RIG_SCORE: 0.8006

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P162L	TCGA-86-A4JF	LUAD	TCGA	DHEFLEVPEA	DEG_COP1_1	0.7582
p.P162L	DO45317	LUAD	ICGC	DHEFLEVPEA	DEG_COP1_1	0.7582
p.H156N	DO23484	LINC	ICGC	DHEFLEVPEA	DEG_COP1_1	0.6312
p.R152Q	TCGA-25-2042	OV	TCGA	DHEFLEVPEA	DEG_COP1_1	0.25
p.R152Q	DO28249	OV	ICGC	DHEFLEVPEA	DEG_COP1_1	0.25
p.R152L	DO50786	LICA	ICGC	DHEFLEVPEA	DEG_COP1_1	0.25
p.A170V	SIDM01112	Osteosarcoma	GDSC	DHEFLEVPEA	DEG_COP1_1	0.1667
p.A170V	SIDM00793	Burkitt's Lymphoma	GDSC	DHEFLEVPEA	DEG_COP1_1	0.1667
p.A170V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DHEFLEVPEA	DEG_COP1_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04217	Alpha-1B-glycoprotein	DEG_COP1_1	155:164	DHEFLEVPEA	COP1	0.7563	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons