DegronMD

Uniprot ID: Q9UGM1

Source protein: Neuronal acetylcholine receptor subunit alpha-9

Source gene: CHRNA9

Class: CBL_PTK

Location: 368:378

E3 ligase: CBL

DEGRON score: 0.9781

ASA_SCORE: 84.4364

COIL: 0.5598

CONS_SCORE: 0.4596

DSS_SCORE: 0.5013

HELIX: 0.4001

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7477

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T371M	TCGA-3B-A9HT	SARC	TCGA	DHLTKVYSKLP	CBL_PTK	0.6312
p.T371M	DO219934	SARC	ICGC	DHLTKVYSKLP	CBL_PTK	0.6312
p.L359I	TCGA-AX-A06F	UCEC	TCGA	DHLTKVYSKLP	CBL_PTK	0.0833
p.L359I	DO41752	UCEC	ICGC	DHLTKVYSKLP	CBL_PTK	0.0833
p.P378S	TCGA-GN-A8LK	SKCM	TCGA	DHLTKVYSKLP	CBL_PTK	0.6752
p.P378S	DO51259	SKCM	ICGC	DHLTKVYSKLP	CBL_PTK	0.6752
p.N381K	DO229505	LAML	ICGC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00993	Plasma Cell Myeloma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00582	Pancreatic Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00234	Other Solid Cancers	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01040	Ovarian Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00496	Thyroid Gland Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00394	Cervical Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00350	Head and Neck Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00619	Thyroid Gland Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00383	Gastric Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00599	Osteosarcoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00242	Osteosarcoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00567	Other Solid Cancers	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00245	Small Cell Lung Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00018	Acute Myeloid Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00359	Colorectal Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01582	Gastric Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01470	Acute Myeloid Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM01320	Pancreatic Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.N381K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.25
p.A384S	DO228974	LICA	ICGC	DHLTKVYSKLP	CBL_PTK	0.1667
p.L377P	SIDM00373	Endometrial Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	0.6471
p.L377P	ACH-000974	Endometrial/Uterine Cancer	CCLE	DHLTKVYSKLP	CBL_PTK	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DHLTKVYSKLP

Degron related mutations and impact score

Drug responses associated with CHRNA9 mutations

All proteins holding degron of DHLTKVYSKLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGM1	Neuronal acetylcholine receptor subunit alpha-9	CBL_PTK	368:378	DHLTKVYSKLP	CBL	0.9781	More...