DegronMD - Q9UGM1(CHRNA9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T371M	TCGA-3B-A9HT	SARC	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.T371M	TCGA-3B-A9HT	SARC	TCGA	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6312
p.T371M	DO219934	SARC	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.T371M	DO219934	SARC	ICGC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6312
p.L359I	TCGA-AX-A06F	UCEC	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.L359I	TCGA-AX-A06F	UCEC	TCGA	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.0833
p.L359I	DO41752	UCEC	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.L359I	DO41752	UCEC	ICGC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.0833
p.S357N	TCGA-EE-A181	SKCM	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.S357N	DO37444	SKCM	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.P378S	TCGA-GN-A8LK	SKCM	TCGA	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6752
p.P378S	DO51259	SKCM	ICGC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6752
p.N381K	DO229505	LAML	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	DO229505	LAML	ICGC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00993	Plasma Cell Myeloma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00993	Plasma Cell Myeloma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00582	Pancreatic Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00582	Pancreatic Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00234	Other Solid Cancers	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00234	Other Solid Cancers	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01040	Ovarian Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01040	Ovarian Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00496	Thyroid Gland Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00496	Thyroid Gland Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00394	Cervical Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00394	Cervical Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00350	Head and Neck Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00350	Head and Neck Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00619	Thyroid Gland Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00619	Thyroid Gland Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00383	Gastric Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00383	Gastric Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00599	Osteosarcoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00599	Osteosarcoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00242	Osteosarcoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00242	Osteosarcoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00567	Other Solid Cancers	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00567	Other Solid Cancers	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00245	Small Cell Lung Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00245	Small Cell Lung Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00018	Acute Myeloid Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00018	Acute Myeloid Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00359	Colorectal Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00359	Colorectal Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01582	Gastric Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01582	Gastric Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01470	Acute Myeloid Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01470	Acute Myeloid Leukemia	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM01320	Pancreatic Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM01320	Pancreatic Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.N381K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.N381K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.25
p.A384S	DO228974	LICA	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.A384S	DO228974	LICA	ICGC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation rewiring degron network	0.1667
p.E366K	DO220903	MELA	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.591
p.L377P	SIDM00373	Endometrial Carcinoma	GDSC	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6471
p.L377P	ACH-000974	Endometrial/Uterine Cancer	CCLE	DHLTKVYSKLP	CBL_PTK	368:378	Mutation altering degron motif	0.6471

Kaplan plot for CHRNA9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHRNA9

UniProt ID: Q9UGM1

Entrez ID: 55584

Protein name: Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHRNA9 in