DegronMD

Uniprot ID: Q9UGM1

Source protein: Neuronal acetylcholine receptor subunit alpha-9

Source gene: CHRNA9

Class: DEG_APCC_DBOX_1

Location: 366:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8262

ASA_SCORE: 90.6333

COIL: 0.4696

CONS_SCORE: 0.4739

DSS_SCORE: 0.4842

HELIX: 0.4791

FCONS_SCORE: 0.9929

RIG_SCORE: 0.7483

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T371M	TCGA-3B-A9HT	SARC	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	0.6312
p.T371M	DO219934	SARC	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.6312
p.L359I	TCGA-AX-A06F	UCEC	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.L359I	DO41752	UCEC	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.S357N	TCGA-EE-A181	SKCM	TCGA	ERDHLTKVY	DEG_APCC_DBOX_1	0.0833
p.S357N	DO37444	SKCM	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.0833
p.N381K	DO229505	LAML	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00993	Plasma Cell Myeloma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00582	Pancreatic Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00234	Other Solid Cancers	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01040	Ovarian Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00496	Thyroid Gland Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00394	Cervical Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00350	Head and Neck Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00619	Thyroid Gland Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00383	Gastric Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00599	Osteosarcoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00242	Osteosarcoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00567	Other Solid Cancers	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00245	Small Cell Lung Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00018	Acute Myeloid Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00359	Colorectal Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01582	Gastric Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01470	Acute Myeloid Leukemia	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM01320	Pancreatic Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.N381K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ERDHLTKVY	DEG_APCC_DBOX_1	0.1389
p.A384S	DO228974	LICA	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.0556
p.E366K	DO220903	MELA	ICGC	ERDHLTKVY	DEG_APCC_DBOX_1	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDHLTKVY

Degron related mutations and impact score

Drug responses associated with CHRNA9 mutations

All proteins holding degron of ERDHLTKVY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGM1	Neuronal acetylcholine receptor subunit alpha-9	DEG_APCC_DBOX_1	366:374	ERDHLTKVY	APC,CDC20,FZR1	0.8262	More...