DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DHPLYSGHP
Uniprot ID:
Q5VUA4
Source protein:
Zinc finger protein 318
Source gene:
ZNF318
Class:
CBL_PTK
Location:
409:417
E3 ligase:
CBL
DEGRON score:
0.7823
ASA_SCORE:
90.9333
COIL:
0.9273
CONS_SCORE:
0.3276
DSS_SCORE:
0.536
HELIX:
0.0502
FCONS_SCORE:
0.9868
RIG_SCORE:
0.6112
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L412I
TCGA-AX-A3FT
UCEC
TCGA
DHPLYSGHP
CBL_PTK
0.6063
p.L412I
DO40801
UCEC
ICGC
DHPLYSGHP
CBL_PTK
0.6063
p.Q408H
TCGA-G7-6797
KIRP
TCGA
DHPLYSGHP
CBL_PTK
0.3056
p.Q408H
DO20917
KIRP
ICGC
DHPLYSGHP
CBL_PTK
0.3056
Drug responses associated with ZNF318 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DHPLYSGHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VUA4
Zinc finger protein 318
CBL_PTK
409:417
DHPLYSGHP
CBL
0.7823
More...
