DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DHSHLLYSTIP
Uniprot ID:
O60716
Source protein:
Catenin delta-1
Source gene:
CTNND1
Class:
CBL_PTK
Location:
90:100
E3 ligase:
CBL
DEGRON score:
0.9788
ASA_SCORE:
85.6818
COIL:
0.7568
CONS_SCORE:
0.3761
DSS_SCORE:
0.5372
HELIX:
0.1585
FCONS_SCORE:
0.9714
RIG_SCORE:
0.7366
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G87R
TCGA-A5-A1OF
UCEC
TCGA
DHSHLLYSTIP
CBL_PTK
0.25
p.Y96D
TCGA-BP-4960
KIRC
TCGA
DHSHLLYSTIP
CBL_PTK
0.8436
p.P100T
TCGA-BR-8363
STAD
TCGA
DHSHLLYSTIP
CBL_PTK
0.7031
p.G87E
TCGA-FI-A2D5
UCEC
TCGA
DHSHLLYSTIP
CBL_PTK
0.25
p.D110Y
DO228948
LICA
ICGC
DHSHLLYSTIP
CBL_PTK
0.0556
p.R82H
DO41758
UCEC
ICGC
DHSHLLYSTIP
CBL_PTK
0.1111
p.R82H
SNU-1040
large_intestine
COSMIC
DHSHLLYSTIP
CBL_PTK
0.1111
p.D80Y
DO41361
UCEC
ICGC
DHSHLLYSTIP
CBL_PTK
0.0556
p.H93D
SIDM00928
Breast Carcinoma
GDSC
DHSHLLYSTIP
CBL_PTK
0.6577
p.H93D
ACH-000857
Breast Cancer
CCLE
DHSHLLYSTIP
CBL_PTK
0.6577
p.H93D
CAL-85-1
breast
COSMIC
DHSHLLYSTIP
CBL_PTK
0.6577
p.G88E
JHU-022
upper_aerodigestive_tract
COSMIC
DHSHLLYSTIP
CBL_PTK
0.2778
p.A103T
HCC2998
large_intestine
COSMIC
DHSHLLYSTIP
CBL_PTK
0.25
p.H102Y
TT2609-C02
thyroid
COSMIC
DHSHLLYSTIP
CBL_PTK
0.2778
Drug responses associated with CTNND1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DHSHLLYSTIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60716
Catenin delta-1
CBL_PTK
90:100
DHSHLLYSTIP
CBL
0.9788
More...
