DegronMD - O60716(CTNND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G87R	TCGA-A5-A1OF	UCEC	TCGA	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.25
p.R354H	TCGA-B5-A0JY	UCEC	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.25
p.Y96D	TCGA-BP-4960	KIRC	TCGA	DHSHLLYSTIP	CBL_PTK	90:100	Mutation altering degron motif	0.8436
p.P100T	TCGA-BR-8363	STAD	TCGA	DHSHLLYSTIP	CBL_PTK	90:100	Mutation altering degron motif	0.7031
p.G87E	TCGA-FI-A2D5	UCEC	TCGA	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.25
p.P338S	TCGA-W5-AA39	CHOL	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.W336R	TCGA-YL-A9WY	PRAD	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1389
p.R360Q	DO1285	BRCA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360Q	DO219771	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360Q	DO43907	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360Q	DO43971	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R357P	DO234287	ESAD	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1667
p.Q340H	DO228905	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.25
p.Q340H	DO228974	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.25
p.D110Y	DO228948	LICA	ICGC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.0556
p.A345S	DO229027	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7588
p.V352L	DO25471	LUAD	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation blocking phosphorylation signal	0.75
p.R338H	DO223287	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.K347Q	DO43041	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6944
p.R82H	DO41758	UCEC	ICGC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.1111
p.R82H	SNU-1040	large intestine	COSMIC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.1111
p.N348S	DO41235	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7069
p.D80Y	DO41361	UCEC	ICGC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.0556
p.C349W	DO42673	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7
p.R357Q	DO42665	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1667
p.K343T	DO43971	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7306
p.H93D	SIDM00928	Breast Carcinoma	GDSC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation altering degron motif	0.6577
p.H93D	ACH-000857	Breast Cancer	CCLE	DHSHLLYSTIP	CBL_PTK	90:100	Mutation altering degron motif	0.6577
p.H93D	CAL-85-1	breast	COSMIC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation altering degron motif	0.6577
p.R344Q	SIDM00893	Breast Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7329
p.R344Q	ACH-000536	Breast Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7329
p.R344Q	BT-20	breast	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7329
p.P361T	SIDM00877	Breast Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0556
p.P361T	ACH-000196	Breast Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0556
p.P361T	HCC1599	breast	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0556
p.Y334H	SIDM01608	Endometrial Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation blocking phosphorylation signal	0.5278
p.Y334H	ACH-000990	Endometrial/Uterine Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation blocking phosphorylation signal	0.5278
p.G88E	JHU-022	upper aerodigestive tract	COSMIC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.2778
p.A103T	HCC2998	large intestine	COSMIC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.25
p.T348S	LOXIMVI	skin	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7116
p.H102Y	TT2609-C02	thyroid	COSMIC	DHSHLLYSTIP	CBL_PTK	90:100	Mutation rewiring degron network	0.2778
p.R342C	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056

Kaplan plot for CTNND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTNND1

UniProt ID: O60716

Entrez ID: 1500

Protein name: Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTNND1 in